I am a CNRS researcher at the Fresnel Institute (Marseille, France). This blog describes my research in nanophotonics and its latest evolution. Hope you'll find some relevant information !
An inexpensive low numerical aperture lens is used instead of a costly conventional high NA microscope objective to detect single molecule
fluorescence, thanks to a latex microsphere set at the lens focus. The graphs below show fluorescence intensity correlation functions obtained with a 0.25NA doublet and a 3 µm microsphere and
reference correlation function with a standard water-immersion 1.2NA microscope objective and no microsphere.
We demonstrate viable FCS experiments at concentrations 1−1000 nM with different objectives costing less than $40. This offers a simple and
low-cost alternative to the conventional complex microscope objectives.
Back from the Plasmonics GRC in Tilton NH last July. As a synthesis, here is my selection of the top 10 hot stuff / challenges in the field for
the next years, from the list that was written at the end of the meeting. The list was voluntary limited to ten items :
Reproducible SERS and hot spot enhancement quantification